Location: Seattle, Washington, United States
Job Category: Research and Early Development
Work Location: 400 Dexter Ave N. 98109
Organization: Translational Medicine
Employee Status: Full-time
Job Type: Regular
We are seeking a new member of our CAR discovery group within Celgene’s Immuno-Oncology and Cell Therapy research organization. This member will work primarily to discover new CARs against novel targets to support our internal oncology CART pipeline. This team member will help shepherd projects from initial target selection, through CAR library generation and large scale screening, up to final candidate nomination. The role will encompass a broad array of responsibilities to not only execute on CAR discovery campaigns but also develop and optimize our overall discovery approach, often working at the intersection of immunology, cell biology, molecular biology, and next generation sequencing.
The ideal candidate will couple a solid technical foundation in molecular and cell biology with an eagerness to thoughtfully design experimental approaches to generate and rapidly narrow a large number of candidate CARs to a small number of highly active leads. An innate desire to push current scientific boundaries is highly preferred.
Core job responsibilities
- Carry out large scale cell-based CAR screening campaigns with a fastidious attention to detail.
- Independently devise, implement, and troubleshoot experiments to characterize the function of CARs within T-cell lines and primary T-cells.
- Develop new molecular biology methods for both screening library and next generation sequencing library generation.
- Analyze experimental data and communicate results to team members, project teams, and the broader research organization.
- Cultivate productive working relationships with colleagues.
- Record experimental details and maintain laboratory notebook.
- Bachelor's degree in a scientific discipline with at least 6 years work experience or Master's degree with at least 4 years work experience in cell biology and/or molecular biology.
- Strong molecular biology skills, including PCR, qPCR, next gen sequencing library generation, and DNA assembly.
- Adept at standard cell biology techniques, such as cell culture, flow cytometry, and gene delivery.
- Experience with laboratory automation is a plus.
- Highly organized in both laboratory execution and data analysis.
- Flexible in the face of a constantly evolving role and organization.
- Respectful of laboratory safety policies and practices.
COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE
At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.
"At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients."
There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.