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Principal Scientist (Ligase Biology), Protein Homeostasis

Req #: 1800820
Location: San Diego, CA US
Job Category: Research and Early Development
Work Location: 10300 Campus Point Drive Suite 100 SIGSD 92121
Organization: Signal
Schedule: 40
Employee Status: Full time
Job Type: Regular
Job Level:
Other Locations:US- CA- San Diego


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The Ligase Biology Group in the Protein Homeostasis Thematic Center of Excellence (PH TCoE) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. 

We are seeking a motivated PhD Scientist and scientific leader with broad experience in and deep understanding of molecular pathology of disease and therapeutic areas.  Previous experience leading matrixed project teams is desirable. In addition, candidates with knowledge of drug development will be prioritized. The successful candidate will work collaboratively in a multi-disciplinary environment to 1) explore disease biology enabling identification of novel drug targets; 2) develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates; and 3) design and execute research strategies that further our understanding of the mechanisms of novel compounds and targets. Responsibilities include studying the biology of various E3 ligases and utilizing complex cellular and other preclinical models to design relevant assays in support of target validation, disease positioning, SAR, mechanism of action, and potential biomarker strategies. The successful candidate will work within and be capable of leading discovery project teams and presenting the strategy and results to senior management.

Protein Homeostasis at Celgene

The PH TCoE at Celgene is one of the fundamental research and early development engines delivering therapeutics to patients.  As a thematic center, the PH TCoE is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company’s most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.

Responsibilities will include but are not limited to the following:

  • Design and conduct essential experiments in cell biology, cellular biochemistry, molecular biology, and assay development.
  • Lead and influence scientific direction at the Project Team level.
  • Develop and implement relevant cell based assays to support identification, optimization, and validation of novel targets and chemical matter
  • Analyze and present data in an organized and timely manner
  • Be positively engaged and have fun.


  • Ph.D. in a scientific discipline with at least 8 years of relevant work experience, preferred.  Bachelor’s degree in a scientific discipline with at least 14 years of relevant work experience or Master’s degree with at least 12 years of relevant work experience also considered.
  • Experience and training in E3 ligase and UPS biology is a plus.
  • Previous hands-on experience with various molecular and cellular technologies including, but not limited to, quantitative PCR, immunofluorescence and manipulation/editing of gene/message/protein via RNAi and/or CRISPR methods is desired.
  • Experience in mammalian cell culture including primary cell culture is required. Excellent communication, presentation, collaboration and organizational skills are required.
  • Previous Project Leadership experience is preferred.
  • Data analysis skills and experience with a variety of scientific software applications are required. Capability to stay focused and deliver high quality data in a timely and well organized manner.
  • Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.



Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
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About Celgene

Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing treatments for our patients.

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