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Scientist I, DMPK

Req #: 1800816
Location: Summit, NJ US
Job Category: Research and Early Development
Work Location: 556 Morris Avenue CELSUMWEST 07901
Organization: Celgene Corporation
Schedule: 40
Employee Status: Full time
Job Type: Regular
Job Level:
Other Locations:US- NJ- Summit West


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.


Scientist I, DMPK


Director, DMPK



PREREQUISITES: Bachelor’s degree in a scientific discipline with at least 10 years work experience OR Masters' degree with at least 8 years experience required. An advanced degree in Chemistry, Biology or Biochemistry or related field plus industry experience is preferred (MS with 10+ years experience or PhD with 2 years experience).  Knowledge of drug metabolism and extensive hands-on mass spectrometry experience is required.

The Scientist I is responsible for performing ADME studies, including metabolite characterization; performing various DMPK activities; managing the technical aspects of studies; and for preparation of study reports.  He/she will work to plan, perform and interpret complex experiments.

Responsibilities will also include, but are not limited to, the following:

With guidance design and conduct metabolite profiling and characterization studies in support of drug development programs, and perform additional studies as needed, including reaction phenotyping, plasma protein binding, half-life determination, mechanism based studies, and analytical support of PK studies. Work with radiolabeled compounds to facilitate metabolite characterization. Perform DMPK studies, including method development, study design, protocol and report preparation, and data interpretation. Apply novel techniques and approaches to address DMPK issues. Help manage laboratory activities, especially record keeping and instrument maintenance. Keep management apprised of project status and current scientific trends using written and oral summaries, as well as presentations. Participate in preparing Nonclinical Development Work Practices and SOPs.

Skills/Knowledge Required:

  • Strong HPLC and mass spectrometry skills and hands-on experience with LC-MS/MS instrumentation.
  • Understanding of in vitro and in vivo techniques used to characterize drug metabolism, pharmacokinetics and drug interactions potential of drug candidates.
  • Extensive experience performing metabolite profiling and characterization
  • Experience working with radiolabeled material.
  • Strong written and verbal communication skills and computer proficiency are required.
  • Ability to multi-task and work in a collaborative team environment.


Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
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Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing treatments for our patients.

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