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Director, Pharmacology

Req #: 1700638
Location: Cambridge, MA US
Job Category: Research and Early Development
Work Location: 200 Cambridge Park Drive CAMBRIDGE2 02140
Organization: Celgene Corporation
Schedule: 40
Shift:
Employee Status: Full time
Job Type: Regular
Job Level:
Travel:
Other Locations:US- MA- Cambridge

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Position Summary:

The Associate Director of Pharmacology will assume primary responsibility for leadership of a small group of pharmacologists and research associates, providing pharmacology, PK/PD and biomarker support to discovery teams, as well as providing guidance and expertise to project teams either directly or through mentorship/management of pharmacologists to assure delivery of candidates to the development organization.   

Broad subject expertise should include:

Experience in identification of relevant pharmacology models to establish in vivo proof of concept and ability to design and interpret pharmacology studies to be conducted inhouse or via management through a CRO/collaboration.  Experience in endpoints/biomarkers to interrogate that could provide guidance to dose and schedule, or to enabling biomarkers in first in man studies. A working knowledge of immunology or inflammation, either by academic training or industry experience, and  in ex vivo or in vitro evaluation of endpoints relevant to mechanism of action for a broad range of targets in the immunology arena.  Experience representing preclinical function at discovery project teams and with broader interaction with research management teams. Experience in managing an internal animal facility that is run in an efficiently and in compliance with all relevant regulations. Experience managing and mentoring research associates and PhD level scientists. Established and evident fluency in explaining experimental designs, technical constraints, and interpretation of data to diverse and energized project teams. Experience organizing and presenting data packages that support the transition of development candidates into early development.

The successful candidate will have excellent communication skills and be required to interface with the biology and chemistry leads on discovery program teams and also to guide and implement in-house PK-PD efforts.  The ability to evaluate and implement appropriate pharmacology models and to design and oversee a wide range of pharmacology experiments is required.  The role requires oversight of Celgene’s in-house pharmacology capabilities in Cambridge, MA and, more broadly, through monitoring and oversight of externally contracted pharmacology studies.  Vendor selection and monitoring for quality assurance will be the responsibility of this individual, either directly or through management of the pharmacology scientists.

Exceptional organizational skills will be required to meet the demands of multiple internal customers with the allocated resources.  It will be expected that the AD will contribute significantly to the development and implementation of the discovery strategy for the Cambridge research unit as well as contribute to the advancement of the drug discovery programs. 

Responsibilities include, but are not limited to, the following:

Directs Celgene Pharmacology, both internally and externally:  The Associate Director will be responsible for leading the overall scientific, technical, and operational efforts of the Pharmacology group in support of Discovery Project Teams.  This will include selecting appropriate models for the therapeutic areas and ensuring the quality and interpretation of the data produced from the experiments, both internally or externally. Scientific Excellence in Discovery:  Will set the standard for high-quality research within the Pharmacology group.  Contributes to regular review of the project strategy and progress towards the nomination of a Development Candidate. Collaboration Opportunities:  Will be responsible for identifying potential collaborations in academia or industry to enhance the function of Pharmacology and the appropriateness of the models employed in support of the Project Teams.  Excellent collaboration with exploratory toxicology in Celgene, San Diego, and with NCD, Summit will be required to promote an efficient transition from the discovery to the development organization. Manages Internal Project Support:  Will be responsible for the quality, quantity, and timeliness of Pharmacology experiments for Project Teams as well as project team representation either directly, or via mentorship of other PhD level pharmacologists.  Will facilitate transition from Discovery to Non-clinical and coordinate execution of plans with key stakeholders.  Will allocate resources and ensure tracking and follow-up as necessary. Department Management:  Will be responsible for setting high standards and building and managing a high-performance group.  Will identify group needs and recruit, hire, promote personnel as appropriate.  Will develop internal talent through coaching, training, and other experiences that meet the needs of the individual and the organization.  Will allocate proper resources for meeting goals and objectives.  Responsible for budget, including external collaboration expenses, capital and personnel requirements. Communications:  Will maintain productive communications with colleagues in biology, chemistry, Development, and the broader Celgene community.  Will establish effective partnerships through inter-disciplinary collaborations, build expertise in current and future analytical technologies, and enable seamless transfer of information across teams. Leadership:

  • Sets high performance expectations and holds others accountable for results.
  • Encourages and introduces new ideas, processes, and approaches.
  • Promotes a culture of scientific and technical excellence, multidisciplinary problem solving, teamwork, flexibility, execution against goals, and effective communication.
  • Anticipates needs, assesses and manages business risks, and organizational dynamics as well as their implications.

Skills/Knowledge Required:

  • PhD in Pharmacology/Immunology or a related discipline
  • 10 + years experience in Discovery and or Development functions in the pharmaceutical industry
  • Scientific knowledge and experience in drug discovery, in vivo or in vitro pharmacology, and immunology/inflammation would be highly desirable. 
  • Excellent leadership, managerial, and problem-solving skills
  • Excellent written and communication skills to effectively represent vision, mission and accomplishments of the Pharmacology group.

#LI-POST

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
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