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Senior Associate Scientist, Upstream Process Development

Req #: 17000734
Location: Summit, NJ US
Job Category: Biologics
Work Location: Summit West 556 Morris Avenue SUMMIT 07901
Organization: Celgene Corporation
Schedule: Full-time
Shift: Day Job
Employee Status: Regular
Job Type: Standard
Job Level: Individual Contributor
Travel: Yes, 5 % of the Time

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

 

This position in Biologics Process Development is to support the development of high-efficiency upstream processes for recombinant protein production. Reporting to the head of Upstream Process Development Group, the successful candidate will perform mammalian cell culture experiments as well as evaluate other innovative technologies at various scales. 

Responsibilities will include, but are not limited to, the following:

1.Designing and conducting small-scale shake flask and bioreactor experiments for cell culture process optimization, which requires some flexible schedule/weekend work. 

2.Leading prototype runs at 200L scale for material generation and to test scale-up strategy 

3.Investigating and manipulating cellular metabolism for process understanding and improvement  

4.Developing in-house cell culture media to achieve high productivity with desired product quality 

5.Evaluating process robustness and developing mitigation strategy for tech transfer and campaign support 

6.Liaising closely with  the cell line and downstream development groups for execution of projects

7.Overseeing laboratory activities including scheduling, equipment maintenance, and vendor communication  

8.Initiating and leading new technology assessment including external collaborations 

9..Writing technical summaries and development reports for efficient knowledge management 

 
#LI-POST

Qualifications
Bio/Chemical Engineering or related field, B.S. with > 6 years industry experience or M.S. with >2 years industry experience.
 
Skills/Knowledge Required:
Hands-on experience with various industrial cell culture experiments                   especially bench-top bioreactor operation
Familiarity with bioreactor control systems, automation, and                                 troubleshooting  
Cell culture media development and/or pilot scale experience 
Knowledge of bioreactor characterization and scale-up/scale down 
Good understanding of biochemistry and cell metabolic pathway
Demonstrated ability to collaborate effectively within a team setting as well         as with external partners 
Proficient in data analysis using statistical tools or programming 
Excellent organizational and time management skills
Excellent verbal and written communication skills

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.


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About Celgene

Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing treatments for our patients.

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