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Senior Scientist, Cell Line Development

Req #: 17000205
Location: Summit, NJ US
Job Category: Research and Early Development
Work Location: 556 Morris Avenue CELSUMWEST 07901
Organization: Celgene Corporation
Schedule: 40
Shift: Day Job
Employee Status: Full time
Job Type: Regular
Job Level: Individual Contributor
Travel: Yes, 5 % of the Time
Other Locations:US- NJ- Summit West

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.  

This Senior Scientist position will lead cell line development activities initially for a bispecific program, support fast FIH development, prepare cell line development report as supporting document for IND filing.  Perform gap analysis and lead commercial cell line development activities. 

Responsibilities will include, but are not limited to, the following:

1.Responsible for establishing internal cell line development platform and generating high producing cell lines.  Will focus on the development of mammalian cell lines in the production of monoclonal antibody and other types of recombinant proteins, including fusion protein, antibody drug conjugates, and bi-specific antibody, for clinical and commercial manufacturing. 

2.Performing key activities associated with production cell line development including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies. 

3.Developing and optimizing new protein expression platform including designing, constructing, and evaluating novel expression constructs and expression system.

4.Understanding IP landscape of novel technologies in cell line development and developing corresponding strategies to ensure FTO.

5.Managing development projects with external partners and outsourcing activities.  

6.Writing technical reports and presenting data in project and group meetings. 

7.Working closely with upstream process development and purification teams to support development activities.

8.Serving as SME for data review and development support in cross functional team.

9.Supervising direct reports as functional team grows.


PhD in Biological Sciences, Molecular Biology, Biochemical Engineering, or relevant discipline with over 6-8 years of industrial cell line development experience

Skills/Knowledge Required:

1.Extensive experience with generating high producing mammalian production cell line. 

2.Experience with DNA cloning, vector design and construction, and genetic characterization of production cell banks is required.  

3.Experience with high throughput immunological assays such as Octet assay, ELISA, and FACS analysis.

4.Extensive and hands on experience with FACS Sorting. 

5.In depth knowledge of antibody technology, protein expression, and regulatory guideline for recombinant protein expression.

6.The candidate must be well organized and have excellent oral and written communication skills with a proven record on publication and presentation in scientific conferences.  

7.Demonstrated ability to think critically, contribute to experiment design, and excellent problem solving and troubleshooting skills.

8.To be able to perform well in cross functional team to drive project according to project timeline. 


Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

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About Celgene

Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing treatments for our patients.

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