Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
This Senior Scientist position will lead cell line development activities initially for a bispecific program, support fast FIH development, prepare cell line development report as supporting document for IND filing. Perform gap analysis and lead commercial cell line development activities.
Responsibilities will include, but are not limited to, the following:
1.Responsible for establishing internal cell line development platform and generating high producing cell lines. Will focus on the development of mammalian cell lines in the production of monoclonal antibody and other types of recombinant proteins, including fusion protein, antibody drug conjugates, and bi-specific antibody, for clinical and commercial manufacturing.
2.Performing key activities associated with production cell line development including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies.
3.Developing and optimizing new protein expression platform including designing, constructing, and evaluating novel expression constructs and expression system.
4.Understanding IP landscape of novel technologies in cell line development and developing corresponding strategies to ensure FTO.
5.Managing development projects with external partners and outsourcing activities.
6.Writing technical reports and presenting data in project and group meetings.
7.Working closely with upstream process development and purification teams to support development activities.
8.Serving as SME for data review and development support in cross functional team.
9.Supervising direct reports as functional team grows.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
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Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing treatments for our patients.