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Senior Scientist, Discovery Immunology

Req #: 16002035
Location: Massachusetts, US
Job Category: Research and Early Development
Work Location: CAMBRIDGE2
Organization: Celgene Avilomics Research
Schedule: Full-time
Shift: Day Job
Employee Status: Regular
Job Type: Standard
Job Level: Individual Contributor
Travel: No

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.

We have an opening for a talented Scientist to join our Immunology & Inflammation Discovery Biology group in Cambridge, MA. The successful candidate will be expected to contribute ideas for new drug discovery projects, provide in vitro pharmacology and biochemical assay support, design and execute on cell biology related experiments to select small molecule as well as antibody drug targets, and perform investigative pharmacology on lead molecules. More specifically, the individual will focus on developing, optimizing and executing functional and mechanistic cell based assays and will lead and/or contribute as an integral member of multi-disciplinary drug discovery project teams pursuing the nomination of clinical drug candidates. In this role, the individual will draw on their strong scientific background in Immunology to provide scientific guidance, leadership in development of new technologies, or advanced strategies in functional assay development. Opportunities to demonstrate superior scientific acumen, supervisory and leadership potential will be provided as part of your career development. We have a high performing, open collaborative environment where you will interact and work side by side with scientists from other departments including biochemistry, chemistry, pharmacokinetics, pharmacology, biotherapeutics, and toxicology. 

Responsibilities will include, but are not limited to, the following:
1.Independently design, execute and interpret series of experiments relating to scientific programs
2.Introduce new methods, platforms and project concepts
3.Represent the biology function on drug discovery teams and deliver on cell biology needs for drug discovery teams of which you are member
4.Supervise associate staff and guide their career development
5.Provide operational oversight of specified instrumentation
6.Maintain an accurate electronic notebook
7.Comply with laboratory safety procedures
8.Process and communicate scientific findings in joint meetings and in written reports or manuscripts



PhD and post-doctoral training in Immunology with at least 7 years of direct and relevant biotechnology or pharmaceutical industry experience


·    A PhD and post-doctoral training in Immunology, with at least 7 years of experience, preferably in industry, with significant focus on Immunology-focused cellular assay development for mechanistic characterization, and lead discovery and optimization of small molecule and biologic therapeutics. Ideally, the individual will have hands on expertise developing and validating functional assays to support drug discovery and target validation efforts.

·    Excellent record of performance and scientific accomplishments as demonstrated by impactful contributions to the scientific community, pipeline contributions, peer reviewed publications and patent applications.

·    Clear evidence of sustained independent thought and creativity in developing and implementing advanced technology and ideas for new drug discovery projects.

·    Individuals with strong leadership, communication skills, and with experience in participating in and/or leading multi-disciplinary project teams are encouraged to apply.

Skills/Knowledge Required:

§  Expert understanding of immunology and inflammation related biology

§  Demonstrated excellence in molecular biology and immunological techniques and extensive hands-on experience in isolation, culture, and characterization of primary immune cells from human and animal tissues

§  Extensive cell-based and biochemical assay development experience with a variety of readouts including proliferation, activation, migration, etc.

§  Hands on experience with technologies including flow cytometry, ELISA, MSD, capillary electrophoresis, and other assays.

§  Integrated cross-functional knowledge of drug optimization 

§  Understanding of accuracy, quality control, statistics, and significance of conclusions

§  Strong presentation and communication skills

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.



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Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing treatments for our patients.

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